This is an easy-to-follow and comprehensive guide to start and run a retail cannabis business. Despite how it looks, a cannabis business can fail. Landlords can reject your proposal outright or never return your calls. Some people don’t want anything to do with weed. The retail cannabis business is in tricky waters, and it can feel frustrating at the start. Whether you are a newcomer or a would-be business owner, the Retail Cannabis Handbook offers a step-by-step guide to opening and appreciating the retail side of the marijuana business.